Brain Cancer Grade II (Low-grade)
Reviewed by Oncology Team, HealOnco | Last updated: 2026-04
What Grade II (Low-grade) Means
Slow growth with some mitotic activity. Examples: diffuse astrocytoma, oligodendroglioma, atypical meningioma. May show IDH mutation.
Treatment Approach for Grade II (Low-grade)
Maximal safe resection. Observation vs. early adjuvant RT/chemotherapy debated; molecular markers guide decisions. TMZ ± RT for incompletely resected tumors.
Survival Rates and Prognosis
The 5-year survival rate for brain cancer at Grade II (Low-grade) is approximately 5–15 year median overall survival depending on age, resection completeness, and molecular features; IDH-mutant tumors have better prognosis than IDH-wildtype.. Survival rates are statistical averages drawn from large patient populations and may not reflect your individual outcome. Factors that influence your specific prognosis include your age, overall health, tumour biology, and how well the cancer responds to treatment.
Important: These numbers are drawn from historical data. Newer treatments available today may improve outcomes beyond what published statistics show. Discuss your individual prognosis with your oncologist.
How Other Stages Compare
| Stage | 5-Year Survival | Treatment |
|---|---|---|
| Grade I (Benign) | 10–20 year overall survival post-resection if completely resected; radiation often deferred. | Surgery alone usually sufficient for completely resected tumors; radiation… |
| Grade III (High-grade/Anaplastic) | 2–5 year median overall survival depending on molecular profile and extent of resection; IDH mutations improve prognosis. | Maximal resection followed by external-beam RT (54–60 Gy) with concurrent and… |
| Grade IV (Glioblastoma, most aggressive) | Median overall survival 12–15 months with standard Stupp protocol; may reach 2 years with aggressive multimodal therapy. IDH-wildtype: ~14 months; IDH-mutant: ~24+ months. | Maximal safe resection, followed by combined chemoradiation (Stupp protocol:… |
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